Robust and efficient gene regulation through localized nuclear microenvironments

Gene expression in nuclear microenvironments for biological control and cancer.

The author is appreciative of the editorial assistance of Elizabeth Bronstein in the preparation of this manuscript. She is a valued member of our research team. The central theme of my research has consistently been to investigate mechanisms that control proliferation and differentiation with emphasis on regulation that is compromised in cancer. Starting as a graduate student, I have been comm...

The dynamic organization of gene-regulatory machinery in nuclear microenvironments.

Nuclear components are functionally linked with the dynamic temporal and spatial compartmentalization, sorting and integration of regulatory information to facilitate its selective use. For example, the subnuclear targeting of transcription factors to punctate sites in the interphase nucleus mechanistically couples chromatin remodelling and the execution of signalling cascades that mediate gene...

Nuclear Microenvironments in Cancer Series PROSPECTS Nuclear Microenvironments in Cancer Diagnosis and Treatment

The nuclear architecture plays an important role in the temporal and spatial control of complex functional processes within the nucleus. Alterations in nuclear structures are characteristic of cancer cells and the mechanisms underlying these perturbations may directly contribute to tumor development and progression. In this review, we will highlight aspects of the nuclear microenvironment that ...

An Arabidopsis dual-localized pentatricopeptide repeat protein interacts with nuclear proteins involved in gene expression regulation.

Following the endosymbiotic acquisition of mitochondria by eukaryotic cells, most of the genes in this organelle were transferred to the nucleus. To maintain mitochondrial biogenesis and function, nuclear and mitochondrial genomes require regulated and coordinated expression. In plant organelles, nuclear-encoded proteins targeted to the organelles control posttranscriptional and posttranslation...

β-Globin Gene Regulation and Nuclear Organisation